| Education
B.S., Biochemistry, Michigan State University, East Lansing,
MI, 1970
Ph.D., Biochemistry, Indiana University, Bloomington, IN,
1983 |
| Research
Ours is an interdisciplinary research program concerned
with the various interactions which occur within an enzyme
and between an enzyme and its bound substrate. Magnetic resonance
techniques, primarily nuclear magnetic resonance but also
including some electron spin resonance, are our main tools
for describing these ineractions. Most of our experimental
studies have involved paramagnetic relaxation enhancement
measurements on substrates bound to ATP utilizing enzymes.
Our interest in isotopic labeling is a direct outgrowth of
our use of nuclear magnetic resonance to describe interactions
and is mainly directed to synthesis of specifically labeled
ATP's and other substrates of the enzymes we have studied.
Our work focuses on finding enzyme and substrate structure
in the bound complex. |
